摘要：Background and Objective: A high body mass index (BMI) has many negative health consequences. Recurrent pregnancy loss (RPL) has become an important issue in pregnancy outcomes. An increasing frequency of RPL not only in undernourished women but also in women with high BMIs suggested that there is an association between these variables. Lack of evidence urged the authors to determine the association between RPL and high BMI to understand the correlation between RPL in women with high BMI so that BMI can be considered in the prevention of RPL with nutritional approaches. Materials and Methods: This evidence-based case report used the population, intervention, control, outcome (PICO) method in the literature search. A literature search was performed by hand searches and database searches in Cochrane Library, Science Direct and PubMed. The included articles were appraised for their results and quality assessment using the Center for Evidence Based Medicine (CEBM) Oxford Appraisal Tools. Results: We found 308 articles; however, only one meta-analysis was included in the qualitative analysis. The article concluded that there was a significant correlation between a high BMI and RPL (OR = 1.34 [95% CI, 1.05-1.70]; p = 0.02), especially in obese patients (OR = 1.75 [95% CI, 1.24-2.46]; p = 0.001). These results were in line with those of several studies and reviews. While remaining unclear, various factors are considered to cause RPL in obesity, such as abnormalities in the hormonal axis, oocyte quality, embryo development, endometrial receptivity and inflammation markers. Conclusion: A high BMI in pregnant women is significantly correlated with a higher incidence of recurrent pregnancy loss. Thus, comprehensive management of prenatal care including a nutritional approach is required to prevent RPL.
关键词：Body mass index; recurrent pregnancy loss; obesity; reproductive diseases; prenatal care
