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  • 标题:Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?
  • 本地全文:下载
  • 作者:Miguel Ribeiro ; Joana Costa ; Isabel Mafra
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2020
  • 卷号:12
  • 期号:7
  • 页码:2100-2119
  • DOI:10.3390/nu12072100
  • 出版社:MDPI Publishing
  • 摘要:Hazelnuts (Corylus avellana L.) have an important role in human nutrition and health. However, they are a common cause of food allergy. Due to hazelnut varietal diversity, variety-dependent differences in the IgE-binding properties may be suspected, which could allow therapeutic strategies based on the use of hypoallergenic varieties to induce desensitization. In a proteogenomic approach, we aimed to evaluate the allergenic potential of a genetically diverse set of hazelnuts (n = 13 varieties). Minor differences were found at the level of genes encoding important allergens, namely Cor a 8, Cor a 9, and Cor a 14. Nevertheless, IgE-reactivity was similar for all varieties using sera from seven allergic individuals. The predominant IgE-reactive proteins were Cor a 9 (100%) and Cor a 1.04 (60%), with the former being the most frequently identified by a two-dimensional gel electrophoresis (2-DE)-based proteomic approach. Therefore, it seems that the conventional exclusion diet will hold its ground for the time being.
  • 关键词:hazelnut allergy; genetic diversity; hazelnut-allergic patients’ sera; proteogenomics; immunoblot; nutrition hazelnut allergy ; genetic diversity ; hazelnut-allergic patients’ sera ; proteogenomics ; immunoblot ; nutrition
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