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  • 标题:Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers
  • 本地全文:下载
  • 作者:Bożena Kociszewska-Najman ; Natalia Mazanowska ; Beata Borek-Dzięcioł
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2020
  • 卷号:12
  • 期号:9
  • 页码:2713-2723
  • DOI:10.3390/nu12092713
  • 出版社:MDPI Publishing
  • 摘要:The rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by measuring the concentration of cyclosporine and its metabolites in the colostrum of seven post-transplant mothers. The mean concentration of cyclosporine in the colostrum was 22.40 ± 9.43 mcg/L, and the estimated mean daily dose of the drug was 1049.22 ± 397.41 ng/kg/24 h. Only three metabolites (AM1, DHCsA, and THCsA) had mean colostrum amounts comparable to or higher than cyclosporine itself, with the daily doses being 468.51 ± 80.37, 2757.79 ± 1926.11, and 1044.76 ± 948.56 ng/kg/24 h, respectively. Our results indicate a low transfer of cyclosporine and its metabolites into the colostrum in the first two days postpartum and confirm the emerging change to the policy on breastfeeding among post-transplant mothers. A full assessment of the safety of immunosuppressant exposure via breastmilk will require further studies with long-term follow-ups of breastfed children.
  • 关键词:breastfeeding; immunosuppression; cyclosporine A; transplant; lactation breastfeeding ; immunosuppression ; cyclosporine A ; transplant ; lactation
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