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  • 标题:Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma
  • 本地全文:下载
  • 作者:Annagrazia Adornetto ; Laura Rombolà ; Luigi Antonio Morrone
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2020
  • 卷号:12
  • 期号:10
  • 页码:3158-3190
  • DOI:10.3390/nu12103158
  • 出版社:MDPI Publishing
  • 摘要:Glaucoma, a leading cause of irreversible blindness worldwide, is an optic neuropathy characterized by the progressive death of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is recognized as the main risk factor. Despite effective IOP-lowering therapies, the disease progresses in a significant number of patients. Therefore, alternative IOP-independent strategies aiming at halting or delaying RGC degeneration is the current therapeutic challenge for glaucoma management. Here, we review the literature on the neuroprotective activities, and the underlying mechanisms, of natural compounds and dietary supplements in experimental and clinical glaucoma.
  • 关键词:glaucoma; neuroprotection; natural products; nutrients; antioxidant; retinal ganglion cells glaucoma ; neuroprotection ; natural products ; nutrients ; antioxidant ; retinal ganglion cells
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