摘要：In response to “Letter: are there non-responders to the ergogenic effects of caffeine ingestion on
exercise performance” by Grgic [1], we welcome the additional context that this letter provides to our
paper [2]. We agree with the sentiment that responders and non-responders are misleading to readers
and thus avoided using these terms in our publication [2] as much as possible. As stated by Grgic [1],
an individual may perform well in one test and not another following caffeine ingestion, likewise the
individual may perform better or worse on different days given the same caffeine supplementation
due to multiple external factors (as mentioned in our paper [2]) and variation in performance.
With regards to the study design of future research, while it may be beneficial to use multiple
exercise modes to determine the ergogenicity of caffeine, it is quite often not realistic to do so within
the same study. Most studies investigating the ergogenic benefits of supplements use a specific exercise
modality to answer a specific research question, for example exploring the effects of caffeine intake on
endurance time-trial performance [3–6]. Including multiple exercise modalities within the same study
would greatly increase the participant burden, financial costs and time to carry out the study. However,
we agree that researchers should still be encouraged to use a variety of valid exercise modalities to
gain a comprehensive understanding of a particular supplement. The recommendations put forward
by Grgic [1] are welcomed and should be applied where applicable, particularly the reporting of
individual data in response to caffeine supplementation as well as when drawing conclusions from
the results.
