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  • 标题:Are Vitamin D3 Tablets and Oil Drops Equally Effective in Raising S-25-Hydroxyvitamin D Concentrations? A Post-Hoc Analysis of an Observational Study on Immunodeficient Patients
  • 本地全文:下载
  • 作者:Maria Helde Frankling ; Anna-Carin Norlin ; Susanne Hansen
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2020
  • 卷号:12
  • 期号:5
  • 页码:1230-1240
  • DOI:10.3390/nu12051230
  • 出版社:MDPI Publishing
  • 摘要:Background: Vitamin D3 supplements are available as tablets or oil drops, but there is no consensus as to whether either of these preparations is more effective than the other. Methods: We compared the effectiveness of tablets versus oil in raising S-25-hydroxyvitamin D (S-25-OHD) in plasma by re-analyzing data from a previously performed observational study in which immunodeficient patients with S-25-OHD concentrations <75 nmol/L were randomly prescribed vitamin D3 tablets (1600 IU/day) or vitamin D3 oil-drops (1500 IU/day) for twelve months. Tablets and oil were compared for the effect on S-25-OHD concentrations after 3–5 months and antibiotic use. Results: Data on S-25-OHD after ≥ 3 months was available for 137 patients treated with tablets and 69 with oil drops. Both groups exhibited a significant increase in S-25-OHD—oil-drops from 55 to 86 nmol/L and tablets from 52 to 87 nmol/L—with no difference between groups (p = 0.77). In a subgroup of patients without immunoglobulin replacement, vitamin D3 supplementation with oil drops (n = 34) but not with tablets (n = 60) resulted in significantly lower antibiotic administration (p < 0.001 and p = 0.58). Conclusion: Vitamin D3 supplementation with tablets and oil drops were equally efficient in raising S-25-OHD concentrations. Only oil drops caused a reduction in antibiotic consumption in immuno-deficient patients who did not receive immunoglobulin replacement.
  • 关键词:vitamin D; Detremin (cholecalciferol); Divisun (cholecalciferol); cholecalciferol; supplementation; clinical trial; infections; antibiotics; oil drops; tablets; S-25-OHD vitamin D ; Detremin (cholecalciferol) ; Divisun (cholecalciferol) ; cholecalciferol ; supplementation ; clinical trial ; infections ; antibiotics ; oil drops ; tablets ; S-25-OHD
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