首页    期刊浏览 2024年11月10日 星期日
登录注册

文章基本信息

  • 标题:Plasma Metabolome Alterations Associated with Extrauterine Growth Restriction
  • 本地全文:下载
  • 作者:Danuta Dudzik ; Isabel Iglesias Platas ; Montserrat Izquierdo Renau
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2020
  • 卷号:12
  • 期号:4
  • 页码:1188-1204
  • DOI:10.3390/nu12041188
  • 出版社:MDPI Publishing
  • 摘要:Very preterm infants (VPI, born at or before 32 weeks of gestation) are at risk of adverse health outcomes, from which they might be partially protected with appropriate postnatal nutrition and growth. Metabolic processes or biochemical markers associated to extrauterine growth restriction (EUGR) have not been identified. We applied untargeted metabolomics to plasma samples of VPI with adequate weight for gestational age at birth and with different growth trajectories (29 well-grown, 22 EUGR) at the time of hospital discharge. A multivariate analysis showed significantly higher levels of amino-acids in well-grown patients. Other metabolites were also identified as statistically significant in the comparison between groups. Relevant differences (with corrections for multiple comparison) were found in levels of glycerophospholipids, sphingolipids and other lipids. Levels of many of the biochemical species decreased progressively as the level of growth restriction increased in severity. In conclusion, an untargeted metabolomic approach uncovered previously unknown differences in the levels of a range of plasma metabolites between well grown and EUGR infants at the time of discharge. Our findings open speculation about pathways involved in growth failure in preterm infants and the long-term relevance of this metabolic differences, as well as helping in the definition of potential biomarkers.
  • 关键词:growth failure; preterm infants; metabolic fingerprinting; multiplatform untargeted metabolomics growth failure ; preterm infants ; metabolic fingerprinting ; multiplatform untargeted metabolomics
国家哲学社会科学文献中心版权所有