摘要:Trehalose (TRE), a disaccharide, is absorbed slowly and gradually increases the blood glucose (GLU) level along with reducing insulin secretion. The aim of this study was twofold. First, we examined exercise performance following ingestions of either GLU, TRE, or water (WAT). The second purpose was to investigate the effects of TRE energy metabolism during prolonged exercise. We examined exercise performance using the Wingate test, with 30-min constant load exercise at 40% VO2peak after exercising for 60 min at 40% VO2peak, by using an electromagnetic brake-type bicycle ergometer (Part 1). The power values, blood glucose and lactate, and respiratory exchange ratio (RER) were measured. In addition, we investigated the energy metabolism after a single ingestion of TRE, by measuring the RER and estimating the lipid oxidation for 60 min at 40% VO2peak (Part 2). Healthy college male students performed three trials—(1) placebo (WAT), (2) GLU, and (3) TRE. Repeated two-way analysis of variance (ANOVA) was used for a comparison of the data among the three trial groups. A multiple comparison test was performed using post hoc Bonferroni correction. The TRE ingestion significantly increased the average and maximum power values (p < 0.01). The TRE ingestion showed significantly higher lipid utilization than the GLU lipid oxidation values the in TRE, 12.5 ± 6.1 g/h; GLU, 9.3 ± 4.7 g/h; and WAT, 15.0 ± 4.4 g/h; (p < 0.01). In conclusion, we provide novel data that a single TRE ingestion was effective in improving prolonged exercise performance by effective use of glucose and lipids.