摘要:One of the problems that have arisen in the past and have an inertial impact on the development of the Russian Federation is the problem of heterogeneity of the country’s socio-economic space. The large scale of the space of Russia predetermines the predominantly macroscopic nature of the regulatory impact, the object of which is large territorial formations: economic districts, federal districts, regions of the Russian Federation. Each separate region, each municipality is a complex system with a set of unique factors: geographic location, climatic conditions, resource potential, population, etc. The article presents the author’s methodology for assessing the differentiation of social and economic development of municipalities in the Voronezh region. In modern conditions, the formation of convenient and effective methods and tools for measuring sustainable social and economic development, which make it possible to give an unambiguous interpretation of the results, is of high value both from a research and management point of view. On the basis of the author’s methodology, an assessment of the differentiation of the social and economic development of municipalities in the Voronezh region has been carried out. The proposed method, having individual characteristics in limiting the number of basic indicators along with the existing approaches, contributes to obtaining more objective results and allows it to be used in the development of a regional social and economic Strategy. These indicators are among the most important areas of the region’s social and economic system.