期刊名称：Croatian Journal of Food Technology, Biotechnology and Nutrition
印刷版ISSN：1847-3423
电子版ISSN：1847-7461
出版年度：2020
卷号：15
期号：3-4
页码：1-28
DOI：10.31895/hcptbn.15.3-4.9
出版社：Hrvatsko društvo prehrambenih tehnologa, biotehnologa i nutricionista
摘要：Influenza (flu) is a viral, contagious, respiratory disease that annually infects up to a billion people worldwide. It appears each year as a seasonal flu, but through history, it appeared as pandemic illness once in every several decades. Its harmful effects on human health and consequently to the society can be prevented by vaccination. The first approved influenza vaccine was made almost 80 years ago using embryonated hen eggs and the same technology is still in use for most available vaccines today. The development of cell biology and improvement of cell culture manufacturing techniques enabled the transition from conventional to novel, more efficient vaccine production methods. In this work we describe the epidemiology of influenza, influenza virus structure as well as current influenza vaccine manufacturing approaches. A brief overview of universal vaccine development and its urgency is discussed in the final section of the paper.
