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  • 标题:Evaluation of Vitamin D Metabolism in Patients with Type 1 Diabetes Mellitus in the Setting of Cholecalciferol Treatment
  • 本地全文:下载
  • 作者:Alexandra Povaliaeva ; Ekaterina Pigarova ; Artem Zhukov
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2020
  • 卷号:12
  • 期号:12
  • 页码:3873-3886
  • DOI:10.3390/nu12123873
  • 出版社:MDPI Publishing
  • 摘要:In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level 0.05 vs. r = 0.88, p < 0.05), possibly due to the glycosylation of binding proteins, which affects the affinity constant for 25(OH)D. The elevation of vitamin D levels after the administration of cholecalciferol was comparable in both groups, with slightly higher 25(OH)D3 levels observed in the diabetes group throughout the study since Day 1 (p < 0.05). Overall, our data indicate that in patients with adequately controlled T1DM 25(OH)D3 levels and the therapeutic response to cholecalciferol is similar to that in healthy individuals.
  • 关键词:vitamin D; type 1 diabetes mellitus; cholecalciferol; vitamin D-binding protein vitamin D ; type 1 diabetes mellitus ; cholecalciferol ; vitamin D-binding protein
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