摘要：There is no standardised protocol for developing clinically relevant guideline questions. We aimed to create such a protocol and to apply it to developing a new guideline. We reviewed international guideline manuals and, through consensus, combined steps for developing clinical questions to produce a best-practice protocol that incorporated qualitative research. The protocol was applied to develop clinical questions for a guideline for general practitioners. A best-practice protocol incorporating qualitative research was created. Using the protocol, we developed 10 clinical questions that spanned diagnosis, management and follow-up. Guideline developers can apply this protocol to develop clinically relevant guideline questions.
关键词：Clinical judgement ; Key clinical questions ; Guideline scope ; Clinical practice guideline ; Implementation ; General practitioner ; GP ; Guideline methodology ; Guideline manual
