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  • 标题:Production of Optically Active Hexahydrocurcumin by Human Intestinal Bacterium in Vitro
  • 本地全文:下载
  • 作者:Toshio Niwa ; Shin-ichiro Yokoyama ; Mika Mochizuki
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2021
  • 卷号:44
  • 期号:1
  • 页码:136-139
  • DOI:10.1248/bpb.b20-00584
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:A hexahydrocurcumin-producing bacterium named 2a1-2b was isolated from human feces. It was observed that the bacterium had more than 99% similarity with Enterococcus avium ATCC14025 T according to 16S ribosomal DNA (rDNA) sequence. The strain 2a1-2b produced optically active 5 R -hexahydrocurcumin (enantiomeric excess (e.e.) > 95%) from tetrahydrocurcumin but not from curcumin. Our results showed that intestine is an important place for producing hexahydrocurcumin.
  • 关键词:hexahydrocurcumin;microflora;optical activity;curcumin
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