期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2020
卷号：67
期号：3
页码：317-322
DOI：10.3164/jcbn.20-21
出版社：The Society for Free Radical Research Japan
摘要：Subjects with a high-negative titer (3–9.9 U/ml) of serum anti- Helicobacter pylori ( H. pylori ) antibody represent a heterogeneous group of currently H. pylori -infected, H. pylori -uninfected, and previously H. pylori -infected cases. We investigated the characteristics of subjects with a high-negative titer during a medical check-up and the utility of H. pylori infection score, the sum of scores of endoscopic findings based on the Kyoto Classification of Gastritis, for diagnosing H. pylori infection. Subjects with 13 C-urea breath test-positive or H. pylori stool antigen test-positive were diagnosed as currently H. pylori -infected. Although around half of subjects with a high-negative titer were after eradication therapy (48.6%), currently H. pylori -infected were considerably confirmed (11.7%). H. pylori infection score showed a high value of area under the receiver operating characteristic curve [0.92; 95% confidence interval (CI), 0.84–1.00] with the most suitable cut-off value of 1.0 (sensitivity: 0.92; specificity: 0.90). Multivariate logistic regression analysis revealed that H. pylori infection score was an independent factor associated with increased prevalence of H. pylori infection (odds ratio, 9.53; 95% CI, 2.64–34.40; p <0.001). Currently H. pylori -infected subjects were considerably included among the subjects with a high-negative titer, and the Kyoto Classification of Gastritis was useful to predict current H. pylori infection.
关键词：Helicobacter pylori;anti-H;pylori antibody;high-negative titer;Kyoto Classification of Gastritis;medical check-up
