摘要：In a previous study, a method of obtaining mean erythrocyte age ( $$M_{RBC}$$ ) from HbA1c and average plasma glucose (AG) was proposed. However, the true value of the hemoglobin glycation constant ( $$k_g$$ dL/mg/day), required for this model has yet to be well characterized. Another study also proposed a method of deriving $$M_{RBC}$$ from erythrocyte creatine (EC). Utilizing these formulae, this study aimed to determine a more accurate estimate of $$k_g$$ . One hundred and seven subjects including 31 patients with hemolytic anemia and 76 subjects without anemia were included in this study. EC and HbA1c data were analyzed, and $$M_{RBC}$$ using HbA1c, AG and the newly-derived constant, $$k_g$$ were compared to $$M_{RBC}$$ using traditional $$^{51}\hbox {Cr}$$ in three patients whose data were taken from previous case studies. A value of $$7.0\times 10^{-6}$$ dL/mg/day was determined for $$k_g$$ . $$M_{RBC}$$ using HbA1c, AG and $$k_g$$ were found to no be significantly different (paired t-test, $$p=0.45$$ ) to $$M_{RBC}$$ using traditional $$^{51}\hbox {Cr}$$ . $$k_g$$ enables the estimation of $$M_{RBC}$$ from HbA1c and AG.
