首页    期刊浏览 2024年11月25日 星期一
登录注册

文章基本信息

  • 标题:What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?
  • 本地全文:下载
  • 作者:Piotr Schulz ; Szymon Hryhorowicz ; Anna Maria Rychter
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2021
  • 卷号:13
  • 期号:2
  • 页码:373
  • DOI:10.3390/nu13020373
  • 出版社:MDPI Publishing
  • 摘要:The endocannabinoid system (ECS) is an endogenous signaling system formed by specific receptors (cannabinoid type 1 and type 2 (CB1 and CB2)), their endogenous ligands (endocannabinoids), and enzymes involved in their synthesis and degradation. The ECS, centrally and peripherally, is involved in various physiological processes, including regulation of energy balance, promotion of metabolic process, food intake, weight gain, promotion of fat accumulation in adipocytes, and regulation of body homeostasis; thus, its overactivity may be related to obesity. In this review, we try to explain the role of the ECS and the impact of genetic factors on endocannabinoid system modulation in the pathogenesis of obesity, which is a global and civilizational problem affecting the entire world population regardless of age. We also emphasize that the search for potential new targets for health assessment, treatment, and the development of possible therapies in obesity is of great importance.
  • 关键词:endocannabinoid system; obesity; cannabinoid receptors; obesity pathogenesis; obesity genes endocannabinoid system ; obesity ; cannabinoid receptors ; obesity pathogenesis ; obesity genes
国家哲学社会科学文献中心版权所有