摘要：Introduction: Coronavirus disease 2019 (COVID‑19) pandemic has caused immense loss of lives, enormous devastation, and has affected lives globally. Timely diagnosis is necessary to contain its spread. While it is important to test symptomatic individuals and high‑risk contacts through reliable and confirmatory test (nucleic acid amplification test [NAAT]) to find out the positive cases of COVID‑19, it is also vital to check their immunity status through the serological tests to find out the varied immunological response in the affected population. Materials and Methods: All NAAT confirmed COVID‑19 patients were included in the study. With a repeat respiratory sample for NAAT, simultaneous serum sample was taken for the detection of IgM and IgG antibodies. Data were compiled and analyzed statistically. Results: During the first repeat NAAT, 71.43% had mounted an antibody response, whereas 28.57% had no response. Irrespective of the antibody status, 68.57% tested positive for SARS‑CoV‑2 virus in NAAT. Although the number dwindled on second repeat NAAT, it raised important questions regarding humoral response and its clinical and diagnostic applicability. Conclusion: Not all, COVID‑19 patients mount a humoral response due to yet unexplained factors. Furthermore, exclusive dependence on serology assays will miss the diagnosis in these patients. More research is needed for description and applicability of humoral response in COVID‑19 patients.
