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  • 标题:Synthesis of Certain New Morpholine Derivatives Bearing a Thiazole Moiety
  • 本地全文:下载
  • 作者:Nurcan Berber
  • 期刊名称:Sakarya University Journal of Science
  • 印刷版ISSN:1301-4048
  • 电子版ISSN:2147-835X
  • 出版年度:2019
  • 卷号:23
  • 期号:4
  • DOI:10.16984/saufenbilder.414310
  • 语种:English
  • 出版社:Sakarya University
  • 摘要:Morpholine is a synthetic simple heterocyclic organic compound having characteristic functional groups of amine and ether. Feasible physicochemical properties (polarity and solubility), low cost and wide availability make it a suitable candidate for the synthesis of many potent drugs. In our work, we synthesized a new series of thiazole substituted morpholine derivatives in two steps. In the first step, thiourea was synthesized in THF at 70-75°C for 24 h and then in the second step the formation of thiazole ring was ensured in EtOH-DMF (5:5 v/v) at 60°C for 24 hours.
  • 关键词:morpholine;thiourea;thiazole
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