出版社：Korean Society of Environmental Health and Toxicology
摘要：This study was done to investigate the protective effect of novel 9-amino-1,2,3,4-tetrahydroacridine derivatives on the hepatoprotective effect intoxicated rats induced by carbon tetrachloride (CCl4). A series of currently derivatives of 9-amino-1,2,3,4-tetrahydroacridine have been prepared through the alkly substitution or the ring expansion for the treatment of the Alzheimer’s disease. The activities of aminotransferase (aspartate and alanine) and contents of alkaline phosphatase,triglyceride and glutathione S-transferase in 9-amino-1,2,3, 4-tetrahydroacridine derivatives pretreated rats were significantly decreased compared to the only carbon tetrachloride treated rats but the contents of cholesterol were increased compared to the only CCl4 treated rats. The result indicated that 9-amino-1,2,3,4-tetrahydroacridine derivatives showed hepatoprotective effect in CCl4 treated rats.
