出版社：Korean Society of Environmental Health and Toxicology
摘要：The aim of current study was to evaluate the toxicity of nonylphenol (NP) on soil nematode,Caenorhabditi elegans.The stress-related gene expression,growth,reproduction and development have been employed to monitor soil toxicity. The 24-h median effect concentrations (LC50s) of NP was 0.15 mg/L. The expressions of vitellogenin-6,vitellogenin-2,cytochrome P450 family protein 35a2 and apoptosis enhancer-1 genes were upregulated in C. elegans by NP exposure. Alterations in growth,reproduction and development were also observed in NP-exposed group and especially hatching failure was observed. The overall results indicate that C. elegans has considerable potential as sensitive markers for NP toxicity monitoring.
关键词：Caenorhabditis elegans;nonylphenol;stress-related gene expressions;growth;reproduction; development
