出版社：Korean Society of Environmental Health and Toxicology
摘要：A series of new derivatives of 1-(5-oxohexyl)-3,7-dimethylxanthine has been prepared for the treatment of the vascular dementia. To investigate hepatoprotective effect of these derivatives,the serum biochemical activity and the histological change of liver tissue were evaluated in carbon tetrachloride (CCl4) treated rats. The activities of aspartate aminotransferase and alanine aminotransferase and the activities of total cholesterol,triglyceride and total bilirubin in 5-oxohexyl-3,7-dimethylxanthine derivatives pretreated rats were significantly decreased compared to the CCl4 only treated rats but the content of glutathione S-transferase was increased compared to the CCl4 only treated rats. These results indicated that 5-oxohexyl-3,7-dimethylxanthine derivatives have hepatoprotective effect in CCl4 intoxicated rats.
