出版社：Korean Society of Environmental Health and Toxicology
摘要：Algal fucoidan is a marine polysaccharide containing sulfur with a wide variety of biological activities including anti inflammatory and anti-thrombotic effects. Although antioxidants can inhibit inflammatory signals through inhibiting activator protein-1 and/or nuclear factorkappaB activation,it is obscure whether fucoi- dan directly scavenges oxy-radicals or indirectly regulates oxidant production and/or antioxidant defense system The antioxidant activities of fucoidan against peroxyl radicals,peroxynitrites and hydroxyl radicals were determined by the total oxy-radical scavenging capacity (TOSC) assay. The specific TOSC values of fucoidan against peroxyl radicals,peroxynitrites or hydroxyl radicals were 282士60,43土1 or 40土1 TOSC/ mg/mL,respectively. These specific TOSC values against peroxyl radicals,peroxynitrites or hydroxyl radicals are 23,12,or 13% of the specific TOSC values of glutathione,a positive control,respectively. These results suggest that fucoidan has direct oxy radical scavenging capacity,which may be related with anti-inflammatory effect of fucoidan.
