出版社：Korean Society of Environmental Health and Toxicology
摘要：To investigate the ffects of carboxyethylgermanium sesquioxide (Ge- 132) on the cyclophosphamide (CY)- induced immunotoxicity,hemagglutinin titer (HA-titer),splenic IgM plaque forming cells (PFC) and contacl- delayed ype hypersensitivity (CDTH) were asessed in mice. Ge-132 was orally administered alone (single dose of 300,600,900 mg/kg b.w.) or with CY (10 or 50 mg/kg. i.p.) to mice on the 2nd day before,simultane- ously with,the 2nd day after immunization. Within Ge- 132 alone treated groups,HA-titer and PFC to SRBC were significantly and dose dependently enhanced when compared with control group. HA-titer and PFC numbers suppressed by the treatment of CY alone were significantly retored by the concomitant treatment of CY and Ge-132. Also,Ge- 132 significantly decreased DNFB induced CDTH and inhibited the CY -enhanced CDTH. These results indieate that Ge-132 may be able to inerease humoral immunity and inhibit the immuno- toxicity by CY.
