出版社：Korean Society of Environmental Health and Toxicology
摘要：The distribution of ambient air particles vanies according to climate,industries,and other sources. In this study,ambient air particles (less than 12.1 um) were monitored from February to Augusl,2007 as 12 different fractions sorted by a cascade impactor. Particles in the size range from 0.33 um to 0.76 μm comprised the main fraction of ambient air particles in Seoul,Korea. On the day of an Asian dust event,the purticle fraction size increased to 1.25~ 2.5 μum. The different sized particle fractions were also monitored for metals and were found to contain toxic heavy metals including Pb,Cd,Hg,Cr and As. Particle preparations were significantly cytotoxic when exposed to culured BEAS 2B clls. Microarray analysis of the treated cells indicated a signifi- cant up-regulation of a number of genes associated with oxidative stress,including meallothionein,heme oxy- genase-I,heat shock protein 70. and NAD(P)H dehydrogenase-l.
