出版社：Korean Society of Environmental Health and Toxicology
摘要：Objectives The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-α) for lung cancer development was evaluated. Methods Genotypes of the TNF-α polymorphisms,-1210C >T,-487A >G,-417A >G,IVS1+123G>A,and IVS3+51A>G,were determined in 616 lung cancer cases and 616 lung cancer-free controls. Results After adjusting for body mass index and smoking,each TNF-α genotype or haplotype composed of five TNF-α single nucleotide polymorphisms did not show an association with lung cancer risk (p >0.05). The statistical power was found to be 88.4%,89.3%,93.3%,69.7%,and 93.9% for 1210C>T,-487A>G,-417A>G,IVS1+123G>A,and IVS3+51A>G,respectively. Furthermore,the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p >0.05). In the repeated analysis with only subjects without other diseases related to inflammation,there was also no association between polymorphisms or haplotypes of the TNF-α gene and lung cancer risk (p >0.05). Conclusions This study found no association between common variants of the TNF-α gene and lung cancer risk.
关键词：Lung cancer risk;Polymorphism;Tumor necrosis factor-alpha
