出版社：Korean Society of Environmental Health and Toxicology
摘要：The effects of bis (B amino-ethyl-oxo) oxalate and bis (a amino-methyl-oxo) oxalate on the toxicity of lead acetate in rast were examined. Rats were given intraperitoneally at the dose of lead acetate 45 mg/kg. The exposure of lead acetate showed the 70% decrease of ALAD (8-amino levulinic acid dehydratase) activity in red blood cell. In vivo 122 mg/kg administration of bis (8-amino-ethyl-oxo) oxalate and bis (a- amino-methy1-oxo) oxalate showed the 50% increase of ALAD activity,whereas 149 mg/ kg administeration of Ca-EDTA had no effect. In vitro,the same results were obtained. Both compounds had hemolytic activity at concentrations higher than that required for showing the 50% ALAD activity increase in vivo.
