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  • 标题:The Effect of Angelicae gigantis Radix on the Benzo(a)pyrene- induced Hepatotoxicity in Rats
  • 其他标题:Benzo(a)pyrene에 의해 유도된 간기능 장해에 미치는 당귀의 효과
  • 本地全文:下载
  • 作者:Soo- Hong Y oon ; Soo- Yeul Cho ; Y oon- Kyung Lee
  • 期刊名称:Environmental Health and Toxicology
  • 电子版ISSN:2233-6567
  • 出版年度:1992
  • 卷号:7
  • 期号:1
  • 语种:English
  • 出版社:Korean Society of Environmental Health and Toxicology
  • 摘要:This study was performed to investigate the effect of Angelicae gigantis Radix extract on the hepatic detoxifying enzyme activities and lipids. Male sprague- dawley rats were administrated the extracts with benzo(a)pyrene,a hepatotoxic agent,induc- ing liver damages. Results obtained from this study were as follows: 1. The markedly increased enzyme activities (AST,ALT,LDH,ALP,γ-GTP,GSH -Px) in B(a)P induced groups tended to be decreased by the treatment of the Angelicae gigantis Radix extract. 2. Liver GSH content and lipid peroxide activity were decreased by the administra- tion of the extracts. 3. It tended that the curative effects were better than the protective effects of the extracts.
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