出版社：Korean Society of Environmental Health and Toxicology
摘要：Recently,concerns of water pollution and health risks caused by synthetic detergents have emerged,as the use of various detergents has increased. It has been suggested that some surfactants are cocarcinogens. The surfactants tested were linear alkylbenzene sulfonate,sodium lauryl sulfate, polyoxyethylene sorbitan monooleat (tween 80),and the mutagens were 1-nitropyrene. N-methyI-N'-nitro-N -nitrosoguanidine,benzo (a) pyrene,and aflatoxin B. This study was undertaken to investigate the effects of surfactants on the activity of mutagens using the Ames mutagenic assay with Salmomella typlimriurm TA98. TA100. The results were summarized as follows: 1. The surfactants have no mutagenic activity of themselves. 2. Higher doses of surfactants than 100 ug/ plate reduced the number of revertants. It is assumed that the reduction would inhibited cell growth. 3. When the comutagenic ratio is defined as the ratio between mutagenic activity itself and the activity with mutagen and surfactant (drinking water quality standard),LAS showed the comutagenic ratio 0.86-1.17 and SLS 0.74-1.10 as well. According to the conparisons,it could not be recognised for the comutagenicity of drinking water quality standard of surfactant. 4. As increasing the amount of mutagens,the designated amount of surfactant did not affected the mutagen's activity' statistically. From the above result,syunthetic surfactants do not present mutagenicity and comutagenicity in the microbial assay. .
