出版社：Korean Society of Environmental Health and Toxicology
摘要：This study was designed to determine the hemolytic mechanism of antitumor agent tetraphosphine platinum (II) complex (RC-1),which was synthesized recently. Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation,methemoglobin synthesis and hemolysis. And also treatment of radical scavengers showed the inhibitory effect of hemolysis and the decrease of malondialde-hyde levels in RC-1 treated erythrocytes. So,the mechanism of hemolysis was considered to be the generation of free radicals,methemoglobin synthesis and the lipid peroxidation of phospholipid which composed of erythrocyte membrane.
