出版社：Korean Society of Environmental Health and Toxicology
摘要：Nerve conduction impairment in lead neuropathy has been empirically linked to altered nerve myo-inositol metabolism. In most cases of neuropathy,abnormal myo -inositol metabolism is associated with abnormal Na+/K+ ATPase provides a potential mechanism to relate defects of the myo-inositol metabolism in the peripheral nerve treated with lead. Therefore,the effect of lead on the rat sciatic nerve Na VK+ ATPase and other ATPase of sciatic nerve was studied. ATPase activity was measured enzymatically in sciatic nerve homogenates from 2-wk lead treated neuropathy rats and age-mached controls administered myo-inositol. Na VK" ATPase components were assessed by ouabain inhibition or the omission of sodium and potassium ions. Lead reduced 50% reduction in the Na+/K+ ATPase activity in homogenates of sciatic nerve. The 50% reduction in the Ka+/K* ATPase activity was selectively prevented by myo -inositol treatment. This study suggests that the toxic mechanism of the lead on peripheral nerve may be through reduction in Na"K+ ATPase activity which has been linked to axonal transport slowing in the rat model of lead neuropathy,via direct changes by the perturbation of the intracelluar sodium or potasium level.
