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  • 标题:Effects of lead on ATPase activity in the sciatic nerve of Sprague - Dawley rat
  • 其他标题:랫드의 대퇴 신경중 ATPase 효소활성에 미치는 납의 영향
  • 本地全文:下载
  • 作者:Myung Kiu Chung
  • 期刊名称:Environmental Health and Toxicology
  • 电子版ISSN:2233-6567
  • 出版年度:1994
  • 卷号:9
  • 期号:1
  • 语种:English
  • 出版社:Korean Society of Environmental Health and Toxicology
  • 摘要:Nerve conduction impairment in lead neuropathy has been empirically linked to altered nerve myo-inositol metabolism. In most cases of neuropathy,abnormal myo -inositol metabolism is associated with abnormal Na+/K+ ATPase provides a potential mechanism to relate defects of the myo-inositol metabolism in the peripheral nerve treated with lead. Therefore,the effect of lead on the rat sciatic nerve Na VK+ ATPase and other ATPase of sciatic nerve was studied. ATPase activity was measured enzymatically in sciatic nerve homogenates from 2-wk lead treated neuropathy rats and age-mached controls administered myo-inositol. Na VK" ATPase components were assessed by ouabain inhibition or the omission of sodium and potassium ions. Lead reduced 50% reduction in the Na+/K+ ATPase activity in homogenates of sciatic nerve. The 50% reduction in the Ka+/K* ATPase activity was selectively prevented by myo -inositol treatment. This study suggests that the toxic mechanism of the lead on peripheral nerve may be through reduction in Na"K+ ATPase activity which has been linked to axonal transport slowing in the rat model of lead neuropathy,via direct changes by the perturbation of the intracelluar sodium or potasium level.
  • 关键词:lead neuropathy;Na+/K+ ATPase activity;myo-inositol
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