出版社：Korean Society of Environmental Health and Toxicology
摘要：To investigate and evaluated the scavenging and antioxidative effects of various flavonoids on paraquat induced toxicity,in vivo and vitro tests of eight flavonoids (catechin,epocatechin,flavone,chrysin,apigenin,quercetin,morin and biochanin A) were carried out. The generation of reactive oxygen substances(ROS) in PMS-NADH system H»0^ induced hemolysis and lipidperoxidation to blood,NADPH dependent lipidperoxidation to liver and lung microsome by paraquat were studied. The results are summerized as follows; 1) In the concentration ranges from 3.3 to 9.8^M of catechin,epicatechin,quercetin and biochanin A removed the 50% 〇f DPPH radical scavenging effects. 2) In the concentration ranges from 0.60 to 1.86 mM of catechin,epicatechin,quercetin and biochanin A showed the inhibitory and antioxidative activity on superoxide anion which gernerated in PMA-NADH system. 3) In the concentration ranges from 0.12 to 0.49mM of catechin,epicatechin. quercetin and biochanin A showed the inhibitory and antioxidative activity on H.*〇2 which generated in PMA-NADH system. 4) In the concentration ranges from 0.6 x i〇"' to 6.3x of catechin,epicatechin. flavone,chrysin,quercetin and morin showed the inhibitory and antioxidative activity on HaO? induced hemolysis to blood 5) All flavonoids tested exhibited inhibitory and antioxidative effects on paraquat induced liver and lung microsomal lipidperoxidation. Therefore,all flavonoids evaluated showed the useful compounds for scavenger and antioxidant on paraquat induced toxicity.
