出版社：Korean Society of Environmental Health and Toxicology
摘要：Furfural,an organic solvent,is widely used as synthetic component material in producing chemical products. However,furfural has been reported that it shows strong toxicities to human being showing intense stimulus to skin,eyes,mucous membrane and nerve system. It is also known to cause anemia,liver cirrhosis,kidney failure and genetic toxicity in the human being working in the exposed area. LI)50 of furfural for peritoneal injected mouse has been known around 20mg/kg,but the acute toxicity on aquatic organisms such as fish,daphnid or algae are not well known,compared to those on rodents. In this experiment,we studied on the fish toxicity of furfural using Japanese Medaka {Oryzias latipes) and Common Carp (CupririKS carpio). We also observed histological changes in the fish organs. The LC50s were 12.8mg/L in Japanese Medaka and 21.8 mg/L in Common Carp,respectively. When Common Carps were exposed to 120 mg/L of furfural concentration for 30 minutes,blood congestion in gills and lysis of secondary lamella were shown. Though the muscle of caudal fin was not completely eroded,its epidermic cells were shown to be necrotic in various parts. Tissue atrophy and cell necrosis were also shown in the liver of Common Carps exposed to furfural. From these results,furfural seems to cause histological damages on liver,an internal organ as well as on external organs such as gills and fins eventhough the fish were exposed for a shortterm.
