摘要：Background: An increasing body of research highlights reconsolidation-based therapies as
emerging treatments for post-traumatic stress disorder (PTSD). The Rewind Technique is
a non-pharmacological reconsolidation-based therapy with promising early results, which
now requires evaluation through an RCT.
Objectives: This is a preliminary efficacy RCT to determine if the Rewind Technique is likely
to be a good candidate to test against usual care in a future pragmatic efficacy RCT.
Methods: 40 participants will be randomised to receive either the Rewind Technique
immediately, or after an 8 week wait. The primary outcome will be PTSD symptom severity
as measured by the Clinician-Administered PTSD Scale for DSM5 (CAPS-5) at 8 and 16 weeks
post-randomisation. Secondary outcome measures include the PTSD Checklist (PCL-5),
International Trauma Questionnaire (ITQ), Patient Health Questionnaire (PHQ-9), the
General Anxiety Disorder-7 (GAD-7), Insomnia Severity Index, the Euro-Qol-5D (EQ5D-5 L),
the prominence of re-experiencing specific symptoms (CAPS-5) and an intervention acceptability questionnaire to measure tolerability of the intervention.
Conclusions: This study will be the first RCT to assess the Rewind Technique. Using a crossover methodology we hope to rigorously assess the efficacy and tolerability of Rewind using
pragmatic inclusion criteria. Potential challenges include participant recruitment and
retention.
