摘要：Preeclampsia (PE) is a very common critical condition during pregnancy. As PE is a highrisk condition during pregnancy, occurring in 25% of all pregnancies, worldwide. In women
with PE there is an increase in hypertension and albuminuria. Elevated blood pressure can be
life-threatening after 20th week of pregnancy. Single nucleotide variation in gene sequence
can be disease causing, among these pathogenic SNPs, a variant in TNF-α, G308A is
analyzed in many studies as a causative variant to cause preeclampsia. In this case control
study fifty patients and fifty healthy individuals were enrolled for analysis of TNF-α
promoter region SNP G308A from Jinnah hospital, Lahore, Pakistan. The genotyping of
TNF-α (G308A) rs1800629 polymorphisms was performed by PCR-RFLP method. Data
analysis was performed by using SNPStats, statistical tool. The mean age of all patients and
controls were calculated, 24.4 ± 6.6 and 25.1 ± 5.3 years, respectively. The frequency of
G308A polymorphism was more prevalent in the case group, in association with control
group (p<0.001). There was a significant correlation between inflammation promoting
genotypes of TNF-α and PE. It can be warily concluded that: TNF- α (G-308A)
polymorphism can be reflected as a marker of predisposition to preeclampsia in our
population.
