标题：Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring
摘要：Objective To examine the role of total mercury (T-Hg) in placenta as a biomarker of prenatal mercury (Hg) exposure and determine the association between prenatal Hg exposure and risk for neural tube defects (NTDs) in offspring. Methods Total Hg concentrations in placental tissue were detected in 408 NTD cases and 593 healthy controls enrolled in Shanxi province in northern China. Methylmercury (MeHg) and T-Hg were also detected in the umbilical cord of 147 NTD cases and 140 healthy controls. In addition, MeHg and T-Hg were detected in fetal kidney, liver, and brain tissues of 51 NTD cases. Spearman’s rank correlation ( r s ) was used to evaluate the correlations between placental T-Hg and T-Hg in umbilical cord and fetal kidney, liver, and brain tissues. The Wilcoxon rank-sum test was used to compare T-Hg amounts between case and control groups. Logistic regression was used to examine the association between placental T-Hg and risk for NTDs. Results Placental T-Hg was significantly correlated with T-Hg in umbilical cord ( r s = 0.479), kidney ( r s = 0.718), liver ( r s = 0.656), and brain ( r s = 0.512) tissues (all p < 0.001). The median (25th percentile–75th percentile) concentration for placental T-Hg in the NTD case group was 8.91 (5.00–17.1) ng/g dry weight (d.w.), significantly higher than that in the healthy control group (4.99 [3.26–7.93] ng/g d.w., p < 0.001). After adjusting for potential confounders, higher levels of T-Hg in placenta were associated with increased risk for NTDs in offspring (OR = 1.76, 95% CI: 1.13–2.76), and a dose–response relationship was found ( p < 0.001). Conclusion The concentration of T-Hg in placenta is a good biomarker for estimating prenatal Hg exposure, which is associated with increased risk for NTDs.
