摘要：What is already known about this topic? In 2018, an association between periconceptional dolutegravir exposure and neural tube defects (NTD) was reported in Botswana. Data from U.S. birth defects and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) surveillance programs had not previously been linked to assess NTD prevalence in births to women with HIV. What is added by this report? Linking of data from birth defects and HIV/AIDS surveillance programs in 15 jurisdictions was done for the first time. The NTD prevalence in HIV-exposed pregnancies during 2013–2017 was estimated to be 7.0 per 10,000 live births, similar to the prevalence in the general population in the 15 jurisdictions and the U.S. estimate. What are the implications for public health practice? Current U.S. recommendations state that dolutegravir is a preferred antiretroviral drug throughout pregnancy (with provider-patient counseling) and an alternative antiretroviral drug in women who are trying to conceive. Although no difference in NTD prevalence in HIV-exposed pregnancies was found, data on the use of integrase strand transfer inhibitors in pregnancy are needed to understand the safety and risks of these drugs during pregnancy.
关键词：HIV;Birth Defects;Neural Tube Defects;Pregnancy;HIV During Pregnancy;HIV/AIDS;MMWR;Morbidity & Mortality Weekly Report
