摘要：Background Several studies have found positive associations between outdoor fine particulate air pollution (≤2.5 μm, PM 2.5 ) and childhood asthma incidence. However, the impact of PM 2.5 composition on children’s respiratory health remains uncertain. Objective We examined whether joint exposure to PM 2.5 mass concentrations and its major chemical components was associated with childhood asthma development. Methods We conducted a population-based cohort study by identifying 1,130,855 singleton live births occurring between 2006 and 2014 in the province of Ontario, Canada. Concentrations of PM 2.5 and its seven major chemical components were assigned to participants based on their postal codes using chemical transport models and remote sensing. The joint impact of outdoor PM 2.5 concentrations and its major components and childhood asthma incidence (up to age 6) were estimated using Cox proportional hazards models, allowing for potential nonlinearity. Results We identified 167,080 children who developed asthma before age 6. In adjusted models, outdoor PM 2.5 mass concentrations during childhood were associated with increased incidence of childhood asthma (Hazard Ratio (HR) for each 1 μg/m 3 increase = 1.026, 95% CI: 1.021–1.031). We found that the joint effects of PM 2.5 and its components on childhood asthma incidence may be 24% higher than the conventional approach. Specific components/source markers such as black carbon, ammonium, and nitrate appeared to play an important role. Conclusions Early life exposure to PM 2.5 and its chemical components is associated with an increased risk of asthma development in children. The heterogeneous nature of PM 2.5 should be considered in future health risk assessments.
关键词：PM 2.5 components ; Asthma ; Early life exposure ; Children
