标题：Cerebral oximetry values in diabetic patients are lower than those in non-diabetic patients during adult cardiac surgery with cardiopulmonary bypass
出版社：Japan Society of Circulation Control in Medicine
摘要：Introduction: Diabetes mellitus (DM) is one of the well-known risk factors of postoperative stroke in cardiac surgery. Cerebrovascular CO 2 reactivity and the changes in cerebral blood flow are impaired in diabetic patients. Regional cerebral oxygen saturation (rSO 2 ) measured using near-infrared spectroscopy (NIRS) has been utilized in cardiac surgery to evaluate cerebral oxygenation. However, the difference of the rSO 2 values between diabetic and non-diabetic patients during cardiopulmonary bypass (CPB) has not been well investigated. The aim of this study was to compare the rSO 2 values of diabetic and non-diabetic patients who underwent cardiac surgery. Methods: Thirty diabetic patients (DM group) and 30 age- and gender-matched non-diabetic patients (NDM [control] group) who underwent coronary artery bypass grafting (CABG), valve surgery, or both utilizing normothermic CPB were retrospectively investigated. The mean values of rSO 2 at nine time points during the entire period of cardiac surgery were measured. Results: The rSO 2 values in the DM group were significantly lower than those in the NDM group (p < 0.01) and the difference between the groups increased with the time after the initiation of CPB. Conclusions: The rSO 2 values in diabetic patients are lower than those in non-diabetic patients during cardiac surgery with normothermic CPB. A further large prospective study will be needed to investigate the relationship between lower rSO 2 values in diabetic patients and postoperative outcomes as well as the mechanism of the lower values.
