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标题：Inspiratory Muscle Training in the Severity of Obstructive Sleep Apnea, Sleep Quality and Excessive Daytime Sleepiness: A Placebo-Controlled, Randomized Trial
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作者：José Carlos Nogueira Nóbrega-Júnior ; Armèle Dornelas de Andrade ; Erika Alves Marinho de Andrade 等
期刊名称：Nature and Science of Sleep
印刷版ISSN：1179-1608
电子版ISSN：1179-1608
出版年度：2020
卷号：Volume 12
页码：1105-1113
DOI：10.2147/NSS.S269360
出版社：Dove Medical Press Ltd
摘要：Purpose :Exercise programs have been considered as an adjuvant treatment in obstructive sleep apnea (OSA). However, few studies have focused on the effects of the inspiratory muscle training (IMT) in reducing the severity and the symptoms of OSA. Patients and Methods :A randomized controlled trial was conducted and approved by the local Ethics Committee. All subjects signed the informed consent form and were randomized into 2 groups: a) IMT group (n = 8), 8 weeks of IMT with 75% of maximal inspiratory pressure (MIP) and b) placebo group (n = 8): subjects performed IMT without load. Results :IMT group showed reduction in the apnea-hypopnea index (AHI) (p = 0.01), in the Berlin questionnaire score (p = 0.001) and an increase in inspiratory muscle strength (p = 0.018). IMT group demonstrated a reduction in the AHI (31.7 ± 15.9 events/h vs 29.9 ± 15.8 events/h; p <0.001), in the Berlin questionnaire scores (2.6 ± 0.5 vs 1.2 ± 0.5; p = 0.016), Pittsburgh Sleep Quality Index (PSQI) score (7.2 ± 3.6 vs 3.7 ± 1.3; p = 0.008), in the Epworth Sleepiness Scale (ESS) (12.5 ± 4.0 vs 7.7 ± 3.0; p = 0.008) and increase in MIP (83.6 ± 26.5 cmH 2 O and 127.9 ± 32.5 cmH 2 O; p = 0.010). Conclusion :The IMT promotes discrete changes in the AHI and improves sleep quality and excessive daytime sleepiness in OSA. Moreover, IMT is a cheap, useful and simple home-based training program and can be considered as an adjunct therapy for OSA patients. © 2020 Nóbrega-Júnior et al.
关键词：adjuvant therapy;exercise training;obstructive sleep apnea symptoms;respiratory exercises