文章基本信息

标题：Orgasmolepsy in Narcolepsy Type 1 Responsive to Pitolisant: A Case Report
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作者：Gaia Pellitteri ; Pierluigi Dolso ; Mariarosaria Valente 等
期刊名称：Nature and Science of Sleep
印刷版ISSN：1179-1608
电子版ISSN：1179-1608
出版年度：2020
卷号：Volume 12
页码：1237-1240
DOI：10.2147/NSS.S286358
出版社：Dove Medical Press Ltd
摘要：We describe a case of a young male patient with narcolepsy type 1 (NT1), who developed generalized cataplexy attacks during sexual intercourses, on which we have obtained a satisfactory control with pitolisant. Orgasmolepsy is an uncommon feature of NT1 that has been poorly described in the literature. The prevalence of this condition is unclear, as it is reasonably underreported by patients for embarrassment and not well investigated by physicians. Pitolisant is a novel treatment for narcolepsy, effective on excessive daytime sleepiness and cataplexy by modulating the histaminergic system. Real-world data collection on pitolisant efficacy and safety is still ongoing. However, pitolisant effectiveness on orgasmolepsy in NT1 has no precedent in the literature. Orgasmolepsy and other sexual disturbances should be actively searched in narcoleptic patients and, if present, may guide clinicians to prefer pitolisant or sodium oxybate, avoiding antidepressants for their possible sexual side effects. © 2020 Pellitteri et al.
关键词：NT1;cataplexy;narcolepsy treatment;sexual dysfunction