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标题：Survival rates of patients with breast cancer in countries in the Eastern Mediterranean Region: a systematic review and meta-analysis
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作者：Khadije Maajani ; Mahmoud Khodadost ; Arash Fattahi 等
期刊名称：Eastern Mediterranean Health Journal
印刷版ISSN：1020-3397
出版年度：2020
卷号：26
期号：2
页码：219-232
DOI：10.26719/2020.26.2.219
出版社：World Health Organization
摘要：Background :Breast cancer is the fourth leading cause of death and disability in the Eastern Mediterranean Region (EMR); although the incidence is lower than in the developed regions, there has been an increasing trend in recent decades. Aims :Our aim was to calculate the pooled survival rate of patients with breast cancer in the EMR. Methods :We searched electronic databases from 1946 to 19 January 2018, without language restrictions. We used a random effect model to estimate pooled 1-, 3-, 5- and 10-year survival rates for patients with breast cancer. Chi-squared and I² index were used to assess between-study heterogeneity. Subgroup analysis and meta-regression were used to investigate the potential source of heterogeneity. Results :We found 80 articles eligible for inclusion in our review. The pooled 1-, 3-, 5- and 10-year survival rates in women with breast cancer in the EMR were 0.95, 0.80, 0.71, and 0.56, respectively. The I² index indicated considerable between-study heterogeneity (all I² > 50%). The 5-year survival rate in the male subgroup was 0.63. The 5-year survival rate of women with breast cancer in age groups ≤ 39, 40-64, and 65 years were 0.74, 0.76 and 0.58, respectively. There was a statistically significant association between the Human Development Index (β = 9, P = 0.01) and decade of study (β = 8.2, P = 0.04) and 5-year survival rate. Conclusions :The survival rate of women with breast cancer in those countries in the EMR which have better health care systems improved in the past decade; women aged 40-64 years had the best survival rate. Copyright © World Health Organization (WHO) 2020. Open Access. Some rights reserved. This work is available under the CC BY-NC-SA 3.0 IGO license (https://creativecommons.org/licenses/by-nc-sa/3.0/igo).
关键词：Eastern Mediterranean Region;breast cancer;meta-analysis;review;survival rate