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  • 标题:Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals
  • 本地全文:下载
  • 作者:Pietro Scaduto ; Adolfo Sequeira ; Marquis P. Vawter
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2020
  • 卷号:10
  • 期号:1
  • 页码:1-8
  • DOI:10.1038/s41598-020-65377-3
  • 出版社:Springer Nature
  • 摘要:The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.
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