摘要：Recent studies have revealed structural and functional abnormalities in amygdala due to Internet addiction (IA) associated with emotional disturbance. However, the role of amygdala connectivity that is responsible for emotion-cognition interactions is largely unknown in IA. This study aims to explore the amygdala connectivity abnormalities in IA. The functional and structural connectivity of bilateral amygdala were examined using seed-based connectivity analysis, and the structural integrity on white mater tracts passing through amygdala was also examined. Additionally, a correlation analysis was performed to investigate the relationship between brain connectivity and duration of IA. We found that IA subjects had decreased negative functional connectivity (FC) between amygdala and dorsolateral prefrontal cortex (DLPFC), and had increased negative FC between amygdala and precuneus and superior occipital gyrus (SOG). While IA subjects had decreased positive FC between amygdala and anterior cingulate cortex (ACC), and had increased positive FC between amygdala and thalamus. The FC between left amygdala and right DLPFC had significant correlation with duration of IA. The structural connectivity and integrity between amygdala and ACC were also decreased in IA subjects. These findings indicate that the amygdala connectivity is altered in IA subjects. The altered FC of amygdala-DLPFC is associated with duration of IA.
