首页    期刊浏览 2025年07月23日 星期三
登录注册

文章基本信息

  • 标题:T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients
  • 本地全文:下载
  • 作者:Arnaud G. L’Huillier ; Victor H. Ferreira ; Cedric Hirzel
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2020
  • 卷号:10
  • 期号:1
  • 页码:1-9
  • DOI:10.1038/s41598-020-67172-6
  • 出版社:Springer Nature
  • 摘要:Little is known about cell-mediated immune responses to natural influenza infection in solid organ transplant (SOT) patients. The aim of our study was to evaluate the CD4 and CD8 responses to influenza A and B infection in a cohort of SOT patients. We collected peripheral blood mononuclear cells at influenza diagnosis and four weeks later from 31 SOT patients during the 2017–2018 influenza season. Infection-elicited influenza-specific CD4 and CD8 T-cell responses were measured using flow cytometry and intracellular cytokine staining and compared to responses following influenza vaccine in SOT patients. Natural infection was associated with a significant increase in CD4 T-cell responses. For example, polyfunctional cells increased from 21 to 782 and from 193 to 1436 cells per 106 CD4 T-cells among influenza A/H3N2 and B-infected patients (p = 0.006 and 0.004 respectively). Moreover, infection-elicited CD4 responses were superior than vaccine-elicited responses for influenza A/H1N1 (931 vs 1; p = 0.026), A/H3N2 (647 vs 1; p = 0.041) and B (619 vs 1; p = 0.004). Natural influenza infection triggers a significant increase in CD4 T-cell responses in SOT patients. Infection elicits significantly stronger CD4 responses compared to the influenza vaccine and thereby likely elicits better protection against reinfection.
国家哲学社会科学文献中心版权所有