出版社：International Medical Journal Management and Indexing System
摘要：The Objectives or the current study was to evaluate and compare the analgesic effect of epidural lidocaine and lidocaine- neostigmine combination in dogs. Six healthy dogs of mixed breed weighing 12–15 kg was selected for this study. All dogs received all treatments in a cross-over design with at least two-week interval. Dogs were premeditated with Xylazine (0.5 mg/kg) and general anesthesia was induced with thiopental sodium (12.5 mg/kg) to perform the lumbosacral puncture. Epidural analgesia was done using either 6 mg/kg of lidocaine 2% or a combination of 6 mg/kg of lidocaine 2%, with 10 µg/kg neostigmine. The degree of analgesia was evaluated using a numerical rating scale. Analgesia was defined as absence of a reaction to pin prick test and pressure from hemostat clamp and was performed after one hour of epidural injection, and thereafter every 10 min until complete recovery. Heart rate (HR), respiratory rate (RR), and rectal temperature (RT) were recorded before (baseline, 0) and at every 10 min, until a complete recovery was observed. HR, RR and RT did not differ between treatments at any time point. The lidocaine–neostigmine combination produced a significant (P < 0.05) longer duration of analgesia than lidocaine alone. Adding neostigmine to epidural administered lidocaine in dogs increases the analgesic effect on both hind limbs and perineal region. Co administration of epidural neostigmine and lidocaine appears to be a useful technique for postoperative analgesia as it increases the duration of analgesia.
