摘要：Introduction: Colorectal cancer (CRC) is one of the
most common cancers in Poland. The aim of this
study was to investigate the clinical significance of
absolute monocyte count, neutrophil-to-monocyte
ratio (NMR) and monocytetolymphocyte ratio
(MLR) in pre- and postoperative blood samples of
patients with CRC.
Materials and Methods: We retrospectively
reviewed medical records of 160 patients diagnosed
with CRC who underwent surgery. Blood samples
were obtained within 3 days before and after the
surgical treatment. Venous blood samples were also
obtained from 42 healthy controls.
Results: Pre- and postoperative NMR were
significantly higher than healthy controls (p<0.0001;
p<0.0001). Moreover, MLR in pre-and postoperative blood samples were higher than voluntaries
(p<0.001; p<0.001). The area under the ROC curve
for pre and postNMR showed that the parameter
exhibits strong diagnostic power (1.000). Pre- and
postMLR had moderate diagnostic power amount
0.751 and 0.746. There is also correlation between
monocyte count in samples obtained before and after
surgery and, lymph node metastasis and size of
lymph node metastasis in both cases. PreNMR value
was significantly associated with venous and
lymphatic invasion and the presence of cancer
deposits. PostNMR was found to correlate with
presence of distant metastasis and cancer cell
deposits (R=0.633, p<0.001; R=0.158, p=0.040).
Moreover, preMLR value was correlated with only
perineural invasion.
Conclusions: Analyzed hematologic markers may
be useful as simply obtained parameters, next to
histopathological examination, that determine a
systemic immune response.
关键词：Colorectal cancer;neutrophil-to-monocyte ratio;monocytetolymphocyte ratio
