文章基本信息

标题：Vitamin D regulation of adipogenesis and adipose tissue functions
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作者：Hataikarn Nimitphong ; Eunmi Park ; Mi-Jeong Lee 等
期刊名称：Nutrition Research and Practice
印刷版ISSN：1976-1457
出版年度：2020
卷号：14
期号：6
页码：553-567
DOI：10.4162/nrp.2020.14.6.553
出版社：KoreaMed Synapse
摘要：Vitamin D insufficiency is associated with obesity and its related metabolic diseases. Adipose tissues store and metabolize vitamin D and expression levels of vitamin D metabolizing enzymes are known to be altered in obesity. Sequestration of vitamin D in large amount of adipose tissues and low vitamin D metabolism may contribute to the vitamin D inadequacy in obesity. Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency. We will review current understanding of vitamin D regulation of adipose biology focusing on vitamin D modulation of adiposity and adipose tissue functions as well as the molecular mechanisms through which vitamin D regulates adipose biology. The effects of supplementation or maintenance of vitamin D on obesity and metabolic diseases are also discussed. ©2020 The Korean Nutrition Society and the Korean Society of Community Nutrition.
关键词：Cholecalciferol;adipogenesis;adipose function;metabolic diseases;obesity