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  • 标题:A comparison of post vaccination hepatitis B surface antibody level on the large and appropriate for gestational age infants
  • 本地全文:下载
  • 作者:Abdoulreza Esteghamati ; Shirin Sayyahfar ; Hossein Ghaemi
  • 期刊名称:Clinical and Experimental Vaccine Research
  • 印刷版ISSN:2287-3651
  • 出版年度:2021
  • 卷号:10
  • 期号:1
  • 页码:47
  • DOI:10.7774/cevr.2021.10.1.47
  • 出版社:KoreaMed Synapse
  • 摘要:Purpose :The aim of this study was to compare the hepatitis B surface antibody (HBs Ab) titer 1 month after the 4th dose of hepatitis B vaccine administration on the large and appropriate for gestational age infants. Materials and Methods :This cross-sectional study was conducted on 7-month-old cases (n=132) divided into two groups of 2-4 kg (group 1: appropriate for gestational age, 63 cases) and >4 kg (group 2: large for gestational age, 69 cases), whom were vaccinated with a four-dose schedule of hepatitis B vaccine in 2016, Tehran, Iran. Results :Mean birth weight of the groups was 2.98±0.528 and 4.19±0.190 kg, respectively. Hepatitis B surface antigen and hepatitis B core antibody were negative in all cases. HBs Ab level in group 1 and 2 was 13,701.00±11,744.439 and 8,997.15±2,827.191, respectively (95% confidence interval of difference, -7,607.44 to -1,800.25). There was a significant difference between the two groups in antibody titration and antibody logarithm level (p=0.002, p=0.0001). Conclusion :Birth weight may affect the response to the hepatitis B virus vaccine administration. © Korean Vaccine Society.
  • 关键词:Birth weight;Hepatitis B;Hepatitis B surface antibody;Hepatitis B vaccines;Hepatitis B virus;Large for gestational age;Vaccines
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