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标题：Fructose Feeding and Hyperuricemia: a Systematic Review and Meta-Analysis
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作者：Kourosh Sayehmiri ; Iraj Ahmadi ; Enayat Anvari 等
期刊名称：Clinical Nutrition Research
印刷版ISSN：2287-3732
出版年度：2020
卷号：9
期号：2
页码：122-133
DOI：10.7762/cnr.2020.9.2.122
出版社：KoreaMed Synapse
摘要：High fructose feeding has been suggested to involve in several features of metabolic syndrome including hyperuricemia (HP). We designed and implemented a study to determine the effect size of fructose intake and the relative risk of HP based on the type of fructose feeding (diet or solution), duration of treatment (2-6, 7-10, and > 10 weeks), and animal race. The required information was accepted from international databases, including PubMed/MEDLINE, Science Direct, Scopus, and etc., from 2009 until 2019 on the basis of predetermined eligibility criteria. The data selection and extraction and quality assessment were performed independently by two researchers. Results were pooled as random effects weighting and reported as standardized mean differences with 95% confidence intervals. Thirty-five studies including 244 rats with fructose consumption were included in the final analysis. The heterogeneity rate of parameters was high (I2 = 81.3%, p 10 weeks; I2 = 82.8%), 3) the animal race (Wistar; I2 = 78.6%, Sprague-Dawley; I2 = 83.9%). Overall, the pooled estimate for the all parameters was significant (p < 0.001). The results of this study indicated that a significant relationship between HP and fructose intake regardless of the treatment duration, animal race, fructose concentration and route of consumption. Copyright © 2020. The Korean Society of Clinical Nutrition.
关键词：Fructose;Hyperuricemia;Meta-analysis;Rats;Systematic review;Uric acid