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标题：Frequency of Codon 306 Mutations in embB Gene of Mycobacterium tuberculosis Resistant to Ethambutol: A Systematic Review and Meta-Analysis
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作者：Bahman Mohammadi ; Rashid Ramazanzadeh ; Bijan Nouri 等
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2020
卷号：11
期号：1
页码：112-118
DOI：10.4103/ijpvm.IJPVM_114_19
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background :Ethambutol (EMB) resistance is a major concern in patients with tuberculosis (TB). The aim of this study was to determine the frequency rate of mutations in the embB 306 gene of Mycobacterium tuberculosis ( M. tuberculosis ) resistant to EMB, based on a systematic review and meta-analysis. Methods :Thirty-seven original articles (1997-2015) that have been published in valid databases were considered for this research. The articles were systematically reviewed for the prevalence and rate of mutations in embB 306 in EMB-resistant M. tuberculosis . Data were analyzed using meta-analysis and random effects models (CI 95%, P < 0.10). Results :With a 6,931 sample size in 37 original articles, the lowest rate was related to EMB resistance that was observed in 2014 with 0.05 (95% CI: 0.04-0.07) and the highest prevalence rate was 0.84 (95% CI: 0.68-1.01), observed in 1997. Lowest and highest prevalence rates of embB 306 gene mutation in M. tuberculosis were 0.03 (95% CI: 0.01-0.07) in 2014 and 0.78 (95% CI: 0.71-1.84) in 2005, in the USA, respectively. Conclusions :The present study revealed the prevalence and association of mutations in the embB 306 gene of M. tuberculosis with resistance to EMB. Detecting EMB-resistant M. tuberculosis can help in controlling and correcting the administration of drugs for patients with TB. Copyright: © 2020 International Journal of Preventive Medicine.
关键词：Codon 306;Mycobacterium tuberculosis;embB gene;ethambutol;mutations